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[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners

[The Record] May 8,2018, have ties with a new Montreal sports analytics research lab in Kitchener

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[Science Direct] August 10, 2018 "Revealing the atomistic details behind the binding of B7–1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study"

[Nature] August 27, 2019 "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors"

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[Daily Bulletin] June 1, 2018, 11 CBB Members Named Outstanding Performance Award Winners

Research interests:

• Cellular-scale retinal imaging and light safety for the eye.
• Pioneer of two-photon excited fluorescence imaging through the pupil of a living primate eye, which enabled my group to be the first to image translucent primate retinal ganglion cells in vivo.
• First to deploy in vivo fluorescence lifetime imaging ophthalmoscopy of the retina at the cellular scale in living human and non-human primate eyes.

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Research Interests:

• Clinical trial design
• Contact lens performance
• Drug delivery
• Ocular biomaterials
• Proteins at interfaces

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University Research Chair

Office of Research - Technology Transfer & Commercialization:

• Long-lasting Eye Drop Delivery Platform for Targeted Ocular Delivery Applications

Research Interests:

• Design/discovery of potential therapeutics to target various diseases
• Understanding the structure and pharmacology of membrane proteins
• Development of in silico methods/tools for sequence, structure and functional analysis
• Inferring the structure-function evolution of proteins
• Protein engineering for biotechnology and pharmaceutical applications

[American Chemical Society] January 23, 2012 "Exploring Inhibitor Release Pathways in Histone Deacetylases Using Random Acceleration Molecular Dynamics Simulations"

[Wiley Online Library] July 27, 2013 "Ligand release mechanisms and channels in histone deacetylases"

[Royal Society of Chemistry] December 19, 2013 "A steered molecular dynamics mediated hit discovery for histone deacetylases"

[Nature Methods] May 8, 2017 "ModelFinder: fast model selection for accurate phylogenetic estimates"

[Royal Society of Chemistry] October 24, 2017 "Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction"

Research Interests:

• Classical and visual optics
• Optical system design, science and engineering
• Psychophysics/human factors
• Visual perception, visual optics math modelling
• Biomedical image processing

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[CBB researcher story] July 29, 2015 "Image processing to automate early glaucoma diagnosis"

Research Interests:

• Biophysics of lipids and lipid-protein interactions

• The role of structural changes and physical properties of lipid template in controlling biological processes and diseases

• Biomedical nanotechnology (lipid films, molecular mechanism of Alzheimer's disease)

• Drug development and delivery systems, antimicrobial peptides in lung disorders

• Fluorescence and atomic force microscopy

• Kelvin probe force microscopy and single molecule force spectroscopy

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[Global Impact] May 2018, studying Alzheimer's at a molecular level to find a cure

[YouTube Lecture] October 1, 2014 "Scanning probe microscopy in biomedical research"

Research Interests:

• Biomedical diagnosis

• Targeted drug delivery

• Environmental monitoring

• DNA-based biosensors and functional polymers

• Nanomaterials, (gold nanoparticles, liposomes, magnetic nanoparticles, quantum dots, graphene hydrogels, hybrid nanomaterials)

• Bioinorganic / Bioanalytical chemistry

University Research Chair

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[Waterloo Stories] February 27, 2013 "Waterloo researcher uses nano-materials to clean water"

Research Interests:

Research Interests:

• Drug discovery
• Rational drug design and medicinal chemistry
• Cancer therapy
• Treatment of neurological disorders (Alzheimer's, Parkinson's)
• Drug discovery/rational design
• Synthesis and biological evaluation of novel organic molecules and peptides/peptidomimics as therapeutic agents

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[Science News] October 22, 2018 "Nekkar lab determines that depression medications can help treat Alzheimer’s disease"

​[Pharmacy News] July 29, 2015 "Waterloo pharmacist examines drug therapies for Alzheimer’s disease"

Research Interests:

• Protein and DNA separation analysis towards disease diagnosis and drug discovery

• Biosensing and Devices (bacterial, proteins, fluorescence)

• Living cell analysis and water toxicity testing

• Lab-on-a-Chip technology (point-of-care biomedical diagnosis , chemical detection, protein separation and identification, environmental testing)

• Micro-scale fluid mechanics, droplet microfluidics and nanofluidics

• High Throughput Screening For Drug Screening
• Manufacturing Nanomaterials and Carbon Management

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Canada Research Chair in Lab-on-a-Chip Technology [Canada Research Chair Profile]

[Waterloo Stories] June 14, 2012 "Creating the tiny future of science"

Research Interests

• Early Cancer Detection
• Eliminating Positive Surgical Margins
• Non-contact Biopsies for Endoscopy 
• Functional Brain Imaging 
• Early Detection and Understanding the Age-related Vision Loss Problems
• Wound Care
• Cardiovascular
• Machine learning/AI

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Research Interests:

• Calcium channel analysis for target drug delivery for treatment of pain, arrhythmias, angina, and potential benefits in treatment of epilepsy and cancer.

• Structure, function and pharmacology of calcium channels and sodium channels

• Structure and function and analysis of NALCN cation channel  and anti-calcium channel toxins

• The Spafford Neurobiology Research Laboratory studies voltage-gated calcium channels, molecular physiology, biophysics, cell biology, protein biochemistry, fluorescence microscopy and tissue cultures.

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[Science News] April 25, 2014 "Waterloo discovers a key regulator in the pacemakers of our brain and heart"

Research Interests:

• Electrophysiological characterization of neuromuscular disorders

• Autonomous and knowledge systems

• Machine perception and sensors

• Image processing and analysis, pattern analysis and recognition

• EMG signal decomposition, simulation and quantitative EMG and DQEMG

• Biomedical engineering

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Research Interests:

• Ultrasound imaging innovations: Complex flow imaging, High-performance beamforming platforms, Flow phantom design

• Therapeutic ultrasound discoveries: Sonoporation, Micro/nanobubble cavitation, Wave-matter interactions, Cellular dynamics studies

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