Contact Info
Department of Applied Mathematics
University of Waterloo
Waterloo, Ontario
Canada N2L 3G1
Phone: 519-888-4567, ext. 32700
Fax: 519-746-4319
PDF files require Adobe Acrobat Reader
MC 5501
Professor Anita T. Layton
Duke University
Understanding Kidney Physiology: A Modeling Approach
The kidney not only filters metabolic wastes and toxins from the body, it also regulates the body's water balance, electrolyte balance, and acid-base balance, blood pressure, and blood flow. Despite intense research, aspects of kidney functions remain incompletely understood. I will discuss how our group use mathematical analysis and modeling techniques to address a host of previously unanswered questions in renal physiology and pathophysiology: Why is the mammalian kidney so susceptible to hypoxia, despite receiving ~25% of the cardiac output? What are the mechanisms underlying the development of acute kidney injury in a patient who has undergone cardiac surgery performed on cardiopulmonary bypass? How is renal blood flow affected by the interactions between negative and positive feedback mechanisms?
Contact Info
Department of Applied Mathematics
University of Waterloo
Waterloo, Ontario
Canada N2L 3G1
Phone: 519-888-4567, ext. 32700
Fax: 519-746-4319
PDF files require Adobe Acrobat Reader
The University of Waterloo acknowledges that much of our work takes place on the traditional territory of the Neutral, Anishinaabeg and Haudenosaunee peoples. Our main campus is situated on the Haldimand Tract, the land granted to the Six Nations that includes six miles on each side of the Grand River. Our active work toward reconciliation takes place across our campuses through research, learning, teaching, and community building, and is co-ordinated within the Office of Indigenous Relations.